Bottom line
A marketed two-component research-peptide combination (BPC-157 + TB-500) sold under the "Wolverine" name, referencing the comic-book character known for rapid healing. It is the most widely recognised peptide blend in research-community contexts. No published study has tested the combination against individual components. Combination synergy is a hypothesis based on separate preclinical evidence for each peptide.
No established or recommended human dose.
Name and formulation variability
| Observed source/date | Claimed components | Claimed amounts | Verification limits |
|---|---|---|---|
| Legion Peptides (2026) | BPC-157, TB-500 | 10 / 10 mg (20 mg total) | Vendor-declared; unverified purity claims |
| Oath Research batch 2604130351 (2026) | BPC-157, TB-500 | 5 / 5 mg; net content 6.11 / 4.85 mg | Vendor-supplied COA; unverified |
| Peptide.Express (2026) | BPC-157, TB-500 | Variable; sold as pre-blended vial or two-vial kit | Vendor-declared; unverified |
| Improved Peptides (2026) | BPC-157, TB-500 | Individual vials only (no pre-blend sold) | Vendor-declared; unverified |
Also known as: Wolverine Stack, BPC-157/TB-500, BPC/TB Blend, Combo Vial: BPC-157/TB-500.
The most common commercial formulation is a 1:1 mass ratio (5/5 or 10/10 mg). This is NOT a 1:1 molar ratio: BPC-157 (~1,419 Da) and TB-500 (either ~4,963 Da for full Tβ4 or ~890 Da for 7-AA fragment) differ substantially in molecular weight. A 10/10 mg blend yields approximately 7.0 µmol BPC-157 and either ~2.0 µmol (full Tβ4) or ~11.2 µmol (7-AA fragment) of TB-500.
Component evidence
| Component | Separate evidence | Evidence for combination | Compatibility/stability evidence |
|---|---|---|---|
| BPC-157 | Hundreds of preclinical studies (primarily Sikiric lab, Zagreb); VEGFR2/NO angiogenesis; rodent tendon, GI, and neurological models; no completed human efficacy trials | No published pharmacokinetic or efficacy study of the combination | No published co-lyophilisation or co-reconstitution stability data |
| TB-500 | Full Tβ4 reached Phase II trials for corneal healing (dry eye); preclinical cardiac, dermal, neural repair data; actin sequestration through LKKTET motif | No published combination study with BPC-157 | TB-500 identity ambiguous (full 43-AA vs 7-AA fragment); co-stability untested |
Combination-specific studies
No published peer-reviewed study has evaluated the BPC-157 + TB-500 combination in a controlled design comparing the blend against each individual component. The claimed synergy is an extrapolation from complementary mechanisms (local angiogenesis + systemic cell migration), not an experimentally demonstrated phenomenon.
Safety and interaction uncertainties
Any adverse event cannot be attributed to one component in a pre-blended vial
The fixed ratio prevents independent dose adjustment
TB-500 molecular-weight ambiguity (43-AA vs 7-AA fragment) means label claims may not reflect actual molar ratios
No human safety data for the combination exists
WADA: BPC-157 is listed under S0; thymosin-β4 and derivatives such as TB-500 are listed under S2.3. Both are prohibited at all times, but not under the same subsection.
Regulatory and product-quality notes
Neither component is FDA-approved
BPC-157 is FDA Category 2 for bulk compounding (contested)
Products are unregulated "research use only" material
Vendor-supplied COAs exist for BPC-157/TB-500 products; these are unverified seller or test-provider reports and have not been independently corroborated
Evidence gaps
No combination pharmacokinetic study
No dose-ratio optimisation study
No study with individual-component control arms
No human efficacy data for either peptide in tissue repair
No long-term safety data
Sources
Aminocore Research. Wolverine Blend Analysis. https://aminocoreresearch.com/articles/wolverine-blend-bpc-157-tb-500 accessed 2026-08-06.
Peptide.Express. BPC-157 + TB-500 Wolverine Stack Guide. https://peptide.express/guides/bpc-157-tb-500-wolverine-research-guide accessed 2026-08-06.
Disclosed Labs. BPC-157 + TB-500 testing data. https://www.disclosedlabs.com/peptides/bpc-157-tb-500 accessed 2026-08-06.
Aminoscope. The BPC-157 + TB-500 blend. https://aminoscope.com/research/bpc-157-tb-500-blend accessed 2026-08-06.
Oath Research. "WOLVERINE" Certificate of Analysis. https://oathresearch.com/lab-results/wolverine-bpc-157-tb-500-batch-2604130351/ accessed 2026-08-06.
Improved Peptides. Wolverine Stack Research Profile. https://improvedpeptides.com/research/wolverine-stack/ accessed 2026-08-06.
World Anti-Doping Agency. 2026 Prohibited List. https://www.wada-ama.org/sites/default/files/2025-09/2026list_en_final_clean_september_2025.pdf