Detailed dose evidence documented for Macimorelin in its monograph — reference only, not dosing recommendations.
Reference only — not a dosing recommendation.
Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
0.5 mg/kg (of the macimorelin active moiety) administered as a single oral solution.
Reconstituted granules in water; administered by a healthcare professional.
GH measured in 4 blood samples over 90 minutes after dosing.
Not for BMI >40 kg/m2 (insufficient validation).
Studied in trials
Studied regimens (not recommendations)
Studied in trials — not a recommended dose
Investigational use for cachexia has been studied (phase 2); no approved therapeutic indication.
Not established
What is not established
The label establishes a single diagnostic exposure, not a treatment regimen. No therapeutic regimen is established or recommended for cachexia or GH-deficiency treatment.