Detailed dose evidence documented for Mecasermin in its monograph — reference only, not dosing recommendations.
Reference only — not a dosing recommendation.
Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
Starting dose: 0.04–0.08 mg/kg SC twice daily. If tolerated for ≥1 week, increase by 0.04 mg/kg per dose to a maximum of 0.12 mg/kg twice daily. Must be administered within 20 minutes before or after a meal or snack to reduce hypoglycemia risk.
Studied in trials
Studied regimens (not recommendations)
Studied in trials — not a recommended dose
Not applicable; approved labeled dosing exists.
Not established
What is not established
Use for secondary IGFD, GH deficiency, idiopathic short stature, adult indications, or any off-label use is not established and not recommended by labeling.