Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
- IV dosing (normal renal function): Adults — 2 g/day divided as 500 mg q6h or 1 g q12h. Pediatric (1 mo+): 10 mg/kg q6h. Neonates: 15 mg/kg initially, then 10 mg/kg q12h (first week of life) or q8h (thereafter). Infuse over ≥60 min. Oral (C. difficile): 125 mg PO QID × 10 d. Staphylococcal enterocolitis: 500 mg to 2 g/day PO in 3-4 divided doses × 7-10 d. Dose in renal impairment: reduce based on renal function; TDM strongly recommended.