Reference only — not a dosing recommendation.
Product-, indication-, and jurisdiction-specific — see the monograph
- The entry summarizes the cited US FDA Adlyxin label for type 2 diabetes.
- Initiate 10 mcg SC once daily within 1 hour before the same meal (preferably the main meal) for 14 days.
- Increase to maintenance dose of 20 mcg SC once daily from day 15.
- Administer SC in abdomen, thigh, or upper arm. If a dose is missed, skip it and resume with the next scheduled dose.
Studied in trials — not a recommended dose
- ELIXA and GetGoal trials used the 20 mcg daily maintenance regimen.
- The 10 mcg initiation dose was added to reduce GI side effects during titration.
- Once-weekly formulation (not developed; only daily dosing studied).
- Effectiveness in patients with HbA1c >10% or severe hyperglycemia.
- Use without concomitant metformin or basal insulin (most trials were add-on therapy).
- Weight management indication — no dedicated trial.
- CV risk reduction claim — ELIXA showed neutrality, not superiority.
Lixisenatide — قسم أدلة الجرعة وطريقة الإعطاء في الدراسة التوثيقية