Approved regimen
Approved labeled regimen (historical)
Product-, indication-, and jurisdiction-specific — see the monograph
- This documents the historical US Refludan regimen; the product is no longer marketed. Never extrapolate this information to "research" material labeled as hirudin.
- Adults: IV bolus 0.4 mg/kg (max 44 mg) over 15-20 sec, followed by IV infusion 0.15 mg/kg/h (max 16.5 mg/h). Adjusted to maintain aPTT ratio 1.5-2.5x baseline. Renal impairment: dose adjustment required. Duration: 2-10 days depending on clinical need.