Detailed dose evidence documented for Tirzepatide in its monograph — reference only, not dosing recommendations.
Reference only — not a dosing recommendation.
Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
Mounjaro (T2D): Initiate at 2.5 mg SC once weekly; increase to 5 mg after 4 weeks. If additional glycemic control needed, may escalate in 2.5 mg increments after ≥4 weeks to max 15 mg once weekly. 2.5 mg is titration only; therapeutic doses are 5/7.5/10/12.5/15 mg.
Zepbound (weight management): Same titration schedule. Continue 5, 10, or 15 mg as the maintenance dose.
Zepbound (OSA): Same titration schedule; 10 or 15 mg maintenance.
Studied in trials
Studied regimens (not recommendations)
Studied in trials — not a recommended dose
All SURPASS and SURMOUNT trials used once-weekly subcutaneous dosing starting at 2.5 mg with 4-week dose-escalation steps. Some Phase 1 and 2 studies also explored fixed-dose and rapid-titration regimens; these are not included in the approved label.
Not established
What is not established
No data support safety or efficacy above 15 mg weekly. Tirzepatide has not been studied in combination with other incretin-based therapies. No data on compounded, oral, or non-subcutaneous routes.