Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
- The label summary below is product-, indication-, and jurisdiction-specific; consult the full current label and a licensed clinician/pharmacist. Sandimmune and Neoral are not bioequivalent and cannot be interchanged without physician supervision and monitoring.
- Neoral (modified cyclosporine, microemulsion): Kidney transplant — 9 ± 3 mg/kg/day divided BID; Liver transplant — 8-12 mg/kg/day divided BID; Heart transplant — 7-10 mg/kg/day divided BID. Rheumatoid arthritis — 2.5 mg/kg/day divided BID, titrated up to 4 mg/kg/day. Psoriasis — 2.5 mg/kg/day divided BID, titrated up to 4 mg/kg/day.
- Sandimmune (non-modified cyclosporine): Kidney transplant — 15 ± 5 mg/kg/day divided BID; Liver transplant — 15 ± 8.5 mg/kg/day divided BID. Significantly lower and more variable bioavailability than Neoral.
- Restasis (ophthalmic emulsion 0.05%): 1 drop BID in each eye, 12 hours apart. Vevye (cyclosporine ophthalmic solution 0.1%): 1 drop BID in each eye.
- Therapeutic drug monitoring by trough whole-blood concentration is mandatory for oral formulations; target range varies by indication, transplant type, and time post-transplant.