Approved regimen
Approved labeled regimen
Product-, indication-, and jurisdiction-specific — see the monograph
- Labeled regimen per Giapreza prescribing information:
- Starting dose: 20 ng/kg/min via IV infusion (central line)
- First 3 hours (titration phase): Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure. The current US label says not to exceed 80 ng/kg/min during the first 3 hours.
- Maintenance (after first 3 hours): Reduce to the lowest effective maintenance dose. Typical maintenance range: 1.25–40 ng/kg/min. Maximum maintenance dose: 40 ng/kg/min (ceiling).
- Titration increments: During the first 3 hours, increase or decrease by ≤15 ng/kg/min every 5 minutes. During maintenance, adjust by 5–15 ng/kg/min every 5–15 minutes as needed.
- Down-titration: Once the underlying shock has sufficiently improved, the current US label directs down-titration every 5–15 minutes by increments of up to 15 ng/kg/min based on blood pressure.